The aim of the study was to determine stress was the factor which triggers further seizures in epilepsy. A total of 100 Epileptic participants who were diagnosed as epileptic by neurologists were recruited. The participants consists of Group-I (GTCS) n=50, Group-II (JME) n=50. Patient selection and diagnosis was based on the criteria of the commission and terminology of the international league against epilepsy. All epileptic participants taken in the study were on treatment with Anti Epileptic Drugs (AED).The present study results shows that the percentages of participants affected by stress in Group-I (GTCS) females (63.6%) are under more stress compared to Males. In Group-II (JME) males (54.5%) were under more stress compared to females. But, when compare between two groups GTCS and JME Group-I epileptic participants were under more stress (62%) compared to Group-II (52%). Stress can be considered as one of the precipitating factor for repeated seizures in epilepsy and the different mechanisms of stress hormones which can activate major pathways like inflammatory, immune and free radical generation can lead to further complications and might be the causes for frequent seizures observed in epilepsy.