This paper investigates on the structural stability and electronic properties of titanium dioxide (TiO2) nanowires of different shapes using first-principle based density functional approach. Out of linear, ladder, and saw tooth shaped atomic configuration, the ladder shape atomic configuration is energetically most stable. After computation of lattice parameters as well as various mechanical properties of nanowire TiO2, it is seen that highest bulk moduli is obtained for linear TiO2 nanowire which shows the highest mechanical strength for the structure whereas ladder configuration has lowest bulk moduli which shows the lowest mechanical strength for the structure. Analysis of various electronic properties show that different configurations of TiO2 nanowires can have different utility as solid state materials. © 2019 IEEE.