Anti-inflammatory and antipyretic potential of ethyl acetate, methanol and aqueous extracts of fruiting bodies of Pleurotus eous were investigated. The dried fruiting bodies of P.eous were extracted with ethyl acetate, methanol and water. The anti-inflammatory effect of the extracts of was performed by carrageenan induced rat paw edema and formalin induced paw edema at doses 500 and 1000mg/kg b.w. The antipyretic effects of extracts of P. eous were investigated at doses 250,500 and 1000mg/kg b.w. using yeast induced pyrexia in rats. P. eous extracts produced significant (P<0.05) dose-dependent inhibition of both phases of the formalin induced pain response in comparison with control. In carrageenan test the extracts caused a significant (P<0.05) inhibition of pain at both the doses used. It also showed significant (P<0.05) reduction in hyperpyrexia in rats throughout the observation period of 5hrs.The results of present study suggest that extracts of P. eous possess potent anti-inflammatory and antipyretic effects and could serve as a base for future drugs.