Application of ammonium dihydrogen orthophosphate as a catalyst in the one pot synthesis of 5-ethoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2-(lH)- one by Biginelli condensation is reported. The effect of temperature and the presence of solvents such as ethanol, acetonitrile, toluene, chloroform, acetic acid, n-hexane, etc. on the activity of the catalyst are studied.

Sumathi S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

N. Ramatchandiran

G. Buvaneswari

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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Journal	Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
ISSN	03764699