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Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review
Published in Elsevier BV
2016
Volume: 584
   
Issue: 1
Pages: 97 - 109
Abstract

NFκB has been known to be a necessary transcription factor for the functioning of nearly all cells in a living organism. For its proper functioning, it talks to several other molecular cofactors and interacts with their functionalities resulting in a convoluted cross talking mesh of signalling networks. To completely understand the working of nuclear factor-kappa B protein, one needs to understand the interactions that occur during its lifecycle, with cofactors from various biological processes. This study attempts to elaborate and bridge the gaps on the cross-talk interactions that NFkB is a part of, during its activation pathway. For this Cytoscape and its various plugins (Cytocopter, Allegro, AgilentLitSearch and Styles) are employed. Other related pathways were also collated and analysed for cross-talk between NfκB and interacting molecules. NFκB was found to mainly interact with E3 ubiquitin ligase, NIK, RIP, TCR, IRAK-1, TLR, TRAF-6, NLR and IL-1, details of which are discussed as a part of this study.

About the journal
JournalData powered by TypesetGene
PublisherData powered by TypesetElsevier BV
ISSN0378-1119
Open Access0