This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (α:β:α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues. © 2013 The Royal Society of Chemistry.

Veera Venkata Ramesh E

Department of Chemistry

School of Advanced Sciences

Vellore Campus

K.N. Vijayadas

S. Dhokale

R.G. Gonnade

P.R. Rajamohanan

G.J. Sanjayan

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Organic and Biomolecular Chemistry

Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids

Journal	Organic and Biomolecular Chemistry
ISSN	14770520