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Synthesis and Antimicrobial Activity of 3-{3-[(4-Chlorophenyl)-Sulphonamido]-Phenyl}-5-Aryl-[delta] 2-Pyrazolines
VS Jamode, , HS Chandak
Published in
2004
Volume: 16
   
Issue: 3
Pages: 1837 - 1837
Abstract
3-(4-Chlorophenyl)sulphonamidoacetophenone and aromatic aldehydes in alcoholic NaOH were condensed to obtain chalcones (1a-h), which on refluxing with 3-chlorophenylhydrazine hydrochloride/semicarbazide hydrochloride in pyridine solvent gave 1-(3-chlorophenyl)/carboxamido-3{3-[(4-chlorophenyl) sulphonami do]phenyl)-5-Aryl-Δ2-pyrazolines (2a-h). The structures of these compounds were established by elemental analysis and spectral analysis (IR, NMR).}, author_keywords={Pyrazolines; Spectral studies; Synthesis}, keywords={aldehyde; chalcone; pyrazoline derivative; semicarbazide derivative; sodium hydroxide, analytic method; antimicrobial activity; article; chemical reaction; derivatization; drug activity; finite element analysis; reaction analysis; structure analysis; synthesis; thin layer chromatography}, chemicals_cas={chalcone, 94-41-7; sodium hydroxide, 1310-73-2}, references={Palaska, E., Aytemir, M., Uzbay, T., Erol, D., (2001) Euro. J. Med. Chem., 36, p. 539; Drummond, J.T., Johnson, G., (1998) J. Heterocylic Chem., 12, p. 1123; Elgemeie, G.E.H., Attia, A.M.E., Farag, D.S., Sherif, S.M., (1994) J. Chem. Soc. Perkin Trans., 1, p. 1285; Batulin, Y.U.M., (1969) Chem. Abstr., 70, pp. 2236a; Patel, P., Koregaonkar, S., Shah, M., Parekh, H., (1996) Farmaco, 51, p. 59; Fernandes, Y.J., Parekh, H., (1997) J. Indian Chem. Soc., 74, p. 59; Hussain, M.I., Kumar, A., (1987) Chem. Abstr., 107, pp. 51773 qs; Ganguli, S.S., Vadaria, M.S., Parikh, A.R., (1996) J. Inst. Chem. (India), 68, p. 1920; Upadhyay, J., Dave, U., Parekh, H., (1991) J. Indian Chem. Soc., 68, p. 413; Sharif, E.L., Ammar, Y.A., (1984) J. Indian Chem. Soc., 61, p. 537; Patel, P., Koregaonkar, S., Shah, M., Parekh, H., (1996) Indian J. Pharma Sci., 58, p. 222; Jamode, V.S., Kakde, B.S., (1979) Indian J. Chem., 17 B, p. 622; Jamode, V.S., Chandak, H.S., (2003) Indian J. Heterocyclic Chem., 12, p. 323; Sarhan, E.-T.Z., Mohamed, S.A., Mikhael, A.N., (1993) Alexandria J. Pharm. Sci., 7, p. 41}, correspondence_address1={Bhagat, P.R.; Dept. of Chemistry, , Lohara, Yavatmal-445 001, India; email: pundlik_bhagat@rediffmail.com}, issn={09707077}, coden={AJCHE}, language={English}, abbrev_source_title={Asian J. Chem.}, document_type={Article}, source={Scopus},
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JournalAsian Journal of Chemistry
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