Substituted prop-2-en-1-ones (1a-e) obtained from 4- phenylsulphonamidoacetophenone, have been condensed with isonicotinic acid hydrazide/semicarbazide hydrochloride to obtain the desired 1-isonicotinoyl/ carboxamido-3-(4-phenylsulphonamidophenyl)-5-aryl-2-pyrazolines (2a-e/3a-e). Synthesized compounds have been characterized by elemental an alysis, spectral analysis (IR & 1H NMR) and screened for their antimicrobial activities.