The aim of this present study was to develop a pH sensitive interpenetrating polymeric network (IPN) hydrogels (HG) based on chitosan-acrylamide-grafted-poly ethylene glycol followed by hydrolysis that are cross-linked with glutaradehyde Olmesartan is an antihypertensive drug was successfully loaded in these IPNHG’s. The HGs formed were characterized by Fourier transform infrared spectroscopy (FTIR) to confirm the grafting and cross linking response, X-ray diffraction (XRD) to monitor drug encapsulation in the polymer matrix. HG’s gels were evaluated for swelling index, drug content, in–vitro release performed in both acidic and basic conditions. The IPN matrix in this study was able to extend the release of Olmesartan more than 12 hours. © 2015, Sphinx Knowledge House. All rights reserved.