Molecularly imprinted polymers (MIPs) are capable of recognizing a particular molecule in presence of others due to the selective cavities on it and thus are known as plastic antibodies. Pindolol (PDL) is a synthetic beta-adrenergic receptor blocking agent and widely used for the treatment of hypertension, cardiac arrhythmia and angina pectoris. Using a combinatorial method PDL imprinted polymers were prepared with three functional monomers viz., itaconic acid, 4-vinylpyridine and methacrylic acid by thermal initiated bulk polymerization technique using ethylene glycol dimethacrylate, 2, 2′-azobisisobutyronitrile and acetonitrile as crosslinker, initiator and solvent respectively. Among the three, PDL-itaconic acid MIP shows the best binding capacity. The PDL imprinted polymer was characterized by FTIR spectra and morphology was studied by SEM images. The binding parameters of MIP and non-imprinted polymer (NIP) were compared by the Freundlich and Langmuir adsorption isotherms. © 2013 Indian Institute of Metals.