Mono, di and trivalent ions containing hydroxyapatite of the formula BiNaCa 3(PO 4) 3OH has been synthesized and the compound's catalytic activity in three component Biginelli condensation was studied. The compound was characterized by powder XRD, FT-IR, SEM and TGA/DTA techniques. The unit cell dimensions of the compound were determined to be a = 9.412(2) , C = 6.92(2) and the unit cell volume is 530.9 3. The substituted hydroxyapatite phase showed enhanced reactivity in the one pot synthesis of 3,4-dihydropyrimidin-2(1H)-one by Biginelli reaction and resulted in an increased yield of the product. © 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Sumathi S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Buvaneswari G

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Ceramics International

An oxyphosphate of formula BiCa4(PO4)3O was prepared and characterized by powder XRD, Fourier transform infrared spectroscopy (FTIR), and SEM-EDAX techniques. The catalytic activity of the synthesized compound was explored in the preparation of 3,4-dihydropyrimidin-2(1H)-one using Biginelli reaction. Influence of parameters such as temperature and solvent on this reaction using this heterogeneous catalyst was studied. A higher yield of 98% of the 3,4-dihydropyrimidin-2(1H)-one was achieved within 120 min of duration at room temperature in the presence of acetic acid (AcOH). © 2017 Taylor &amp; Francis Group, LLC.

Inorganic and Nano-Metal Chemistry

Room temperature synthesis of 3,4-dihydropyrimidin-2(1H)-one using apatite like oxyphosphate

Aliovalent ion substituted fluorapatite of formula Bi0.5Na0.5Ca4(PO4)3F was synthesized by co-precipitation method and characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy dispersive X-ray spectroscopy. The catalytic activity of the synthesized compound was tested on one pot multicomponent reaction (Biginelli reaction) for the synthesis of 3,4-dihydropyrimidin-2(1H)-one and its derivatives. The compounds were confirmed by spectroscopic techniques and melting point. An enhanced yield was observed with this catalyst for the condensation of ethyl acetoacetate, urea and benzaldehyde compared to unsubstituted fluorapatite.

Reaction Kinetics, Mechanisms and Catalysis

Synthesis, characterization and catalytic activity of modified fluorapatite towards the multicomponent one-pot Biginelli condensation

Structure of hydroxyapatite (HAP) is more flexible towards ionic substitutions. Properties such as solubility, antimicrobial property can be tailored by substitutions. Substituted hydroxyapatite and fluorapatite of formulae BiNaCa3(PO4)3OH, Bi0.5M0.5Ca4(PO4)3OH (M=K, Ag), Ca10−xCux(PO4)6(OH/F)2 d(x=0.05–0.25) and Bi0.5Na0.5Ca4(PO4)3F were synthesized and characterized by powder XRD, FT-IR, SEM–EDAX and TGA. In vitro solubility of the synthesized compounds was studied in the phosphate buffered medium of pH 7.4 at 37&nbsp;°C. Based on the release of calcium and phosphorus ion concentration and pH, the solubility of these compounds is discussed. Bismuth and sodium co-substituted hydroxyapatite are found to be more soluble compared with other substituted apatite compounds and unsubstituted hydroxyapatite.

Journal of Crystal Growth

In vitro degradation of multisubstituted hydroxyapatite and fluorapatite in the physiological condition

Aliovalent ion substituted hydroxyapatite of formulae BiNaCa3(PO4)3OH, Bi0.5M0.5Ca4(PO4)3OH (M&nbsp;=&nbsp;K, Ag) were synthesized and characterized. Antimicrobial properties of these synthesized materials were studied quantitatively by spread plate method against the microorganisms Escherichia coli (gram negative bacteria), Staphylococcus aureus (gram positive bacteria) and Candida albicans (yeast). Among the substituted hydroxyapatite compounds bismuth and silver substituted compound of formula Bi0.5Ag0.5Ca4(PO4)3OH shown excellent activity against all the three organisms. Cytotoxicity study was carried out against mouse fibroblast NIH-3T3 cell line in two different concentrations 10&nbsp;μg/mL and 20&nbsp;μg/mL by MTT assay method.

Applied Surface Science

Antimicrobial and cytotoxicity evaluation of aliovalent substituted hydroxyapatite

Synthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineering

ChemInform

ChemInform Abstract: Study of Catalytic Activity of Ammonium Dihydrogen Orthophosphate in the Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one.

Tetrahedron Letters

A one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by triphenylphosphine as Lewis base

Catalysis Communications

Alumina supported MoO3: An efficient and reusable heterogeneous catalyst for synthesis of 3,4-dihydropyridine-2(1H)-ones under solvent free conditions

Journal of the Iranian Chemical Society

Fe(HSO4)3 as an efficient catalyst for the preparation of 3,4-dihydropyrimidin-2(1H)-ones in solution and under solvent-free conditions

Synthesis of apatite structure based BiNaCa3(PO4)3OH and its application for condensation reaction

Journal	Data powered by TypesetCeramics International
Publisher	Data powered by TypesetElsevier BV
ISSN	0272-8842
Open Access	0