We have synthesized furan-based vanadium complexes, bis(5-nitrofuran-2- carboxylato)oxovanadium(IV) - [VO(5NF)2], bis(1-furan-2-yl- ethanonato)oxovanadium(IV) sulfate - [VO(2AF)2]SO4, and bis(5-methyl-2-furalato)oxovanadium(IV) sulfate - [VO(MFFA)2]SO 4 possessing [VO(O4)] coordination mode. These complexes are characterized by physico-chemical and spectroscopic methods. Based on electron paramagnetic resonance parameters, the proposed geometry is close to a distorted square pyramid. Animal study was carried out using standard protocol and the complete profile of glucose, protein, and total cholesterol levels were analyzed followed by an oral glucose tolerance test. © 2011 Taylor &amp; Francis.

Sheela A

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Vijayaraghavan R

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Synthesis, spectral characterization, and antidiabetic study of new furan-based vanadium(IV) complexes

Journal of Coordination Chemistry

Diabetes mellitus is one of the metabolic disorders resulting from excess production of reactive oxygen species (ROS) over the normal level and also due to dysfunction in the antioxidant defense mechanism, possibly both occurring simultaneously. Excess ROS are normally scavenged by antioxidants. Transition metal complexes exhibit such antioxidant property by scavenging the excess free radicals (one type of ROS) in such disorders. In this study, we report on synthesis, characterization, and in vitro study on antioxidant property of a few new ester-based vanadium(IV) complexes, namely, bis(1,1- dimethylethylpropanedioato)oxovanadium(IV) - [VO(DTBM)2]; bis(methyl-3-oxopentanoato)oxovanadium(IV) - [VO(MPA)2]; bis(ethyl-3-oxopentanoato)oxovanadium(IV) - [VO(EPA)2]; bis(2-methyl-1,3-dimethylpropanedioato)oxovanadium(IV) - [VO(DMMM)2] and bis(2-bromo-1,3-diethylpropanedioato)oxovanadium(IV) - [VO(BDEM) 2], and also furan-based vanadium complexes. Antidiabetic potential of selected complexes has been estimated. An attempt has also been made to correlate antioxidant and antidiabetic potentials of selected complexes. Our study reveals that compounds exhibiting higher glucose lowering effect seem to possess good antioxidant potential as well. © 2012 Springer Science+Business Media New York.

Medicinal Chemistry Research

A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes

The ester-based vanadium complexes, bis(methylacetoacetato) oxovanadium (IV), bis(ethylacetoacetato) oxovanadium(IV) and bis(ethylbenzoylacetato) oxovanadium(IV), have been prepared and characterized by physicochemical and spectroscopic methods. The biological efficacies of the complexes were investigated. These complexes possess substantial glucose lowering ability and also show improved glucose tolerance effect. © 2010 Springer Science+Business Media B.V.

Transition Metal Chemistry

A study on the glucose lowering effects of ester-based oxovanadium complexes

Since 1985, when Heyliger et al. first reported the in vivo insulin mimetic activity of oral vanadate, extensive studies exploring vanadium chemistry, including the synthesis of novel complexes and their biological effects both in vitro and in vivo have been pursued. Such complexes have emerged as possible potential agents for diabetes therapy. Among the several existing compounds, diketone based vanadium complexes have been chosen for the current study. Two new complexes namely bisdimethylmalonatooxovanadium(IV) and bisdiethylmalonatooxovanadium(IV) have been synthesized and characterized by UV-visible, FTIR and mass spectral studies. The antidiabetic activity of the complexes was proved by animal study. The results show that the above complexes have comparable antidiabetic potential with respect to the standard drug as well as with bisacetylacetonatooxovanadium(IV) which has been studied earlier by Reul et al. © 2008 Elsevier Masson SAS. All rights reserved.

Journal	Journal of Coordination Chemistry
Publisher	Informa UK Limited
ISSN	0095-8972
Open Access	0