New bisphosphoramides (having phenyl (EDAPOPh2) and ethoxy (EDADEP) substituents attached to phosphoryl groups bridged with ethylenediamine spacer) are synthesized and structurally characterized by spectroscopic techniques as well as elemental analysis. The molecular structure of EDAPOPh2was determined by single crystal X-ray diffraction technique. The interaction of these bisphosphoramides with calf thymus DNA (ct-DNA) is investigated using UV–Visible absorption and fluorescence spectral data as well as the DFT calculations. These studies reveal that EDAPOPh2and EDADEP interact with DNA in a partial intercalation mode. The intrinsic binding constants Kbof two different bisphosphoramides with ct-DNA were determined by fluorescence spectroscopy as 2.08 × 104and 3.86 × 104M−1respectively. The results indicated that the two compounds bind to ct-DNA with different binding affinities, i.e. EDAPOPh2&gt; EDADEP. The binding mechanism of these bisphosphoramides to ct-DNA is also discussed. © 2017

Akella Sivaramakrishna

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Veerashekhar Goud E

Vijayakrishna K

Brahmmananda Rao C.V.S

Khedkar V.M

Jha P.C.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Inorganica Chimica Acta

AbstractThree different alicyclic substituents H-phosphonates, namely, dicyclopentyl H-phosphonate, dicyclohexyl H-phosphonate and dimenthyl H-phosphonate were synthesized and used for liquid–liquid extraction of actinide elements (U, Am and Th) and lanthanide (Gd) in

Fulltext

Radiochimica Acta

Experimental and theoretical studies on extraction of actinides and lanthanides by alicyclic H-phosphonates

Nonviral gene delivery vectors are acquiring greater attention in the field of gene therapy by replacing the biological viral vectors. DNA-cationic polymer complexes are one of the most promising systems to find application in gene therapy. Hence, a complete insight of their biophysical characterization and binding energy profile is important in understanding the mechanism involved in nonviral gene therapy. In this investigation, the interaction between calf thymus DNA (ctDNA) and imidazolium-based poly(ionic liquids) (PILs) also known as polyelectrolytes with three different alkyl side chains (ethyl, butyl, and hexyl) in physiological conditions using various spectroscopic experiments with constant DNA concentration and varying polyelectrolyte concentrations is reported. UV-visible absorption, fluorescence quenching studies, gel electrophoresis, circular dichroism (CD), and Fourier transform infrared spectroscopy (FTIR) have confirmed the binding of polyelectrolytes with DNA. UV-vis absorption measurements and fluorescence quenching revealed that the binding between DNA and the polyelectrolyte is dominated by electrostatic interactions. Additionally, CD and FTIR results indicated that the DNA retained its B-form with minor perturbation in the phosphate backbone without significant change in the conformation of its base pairs. Preference for alkyl side chains (KPIL-Ethyl Br &lt; KPIL-Butyl Br &lt; KPIL-Hexyl Br) toward efficient binding between the polyelectrolyte and DNA was inferred from the binding and quenching constants calculated from the absorption and emission spectra, respectively. Further, in silico molecular docking studies not only validated the observed binding trend but also provided insight into the binding mode of the polyelectrolyte-DNA complex. (Chemical Equation Presented). © 2015 American Chemical Society.

Biomacromolecules

Biophysical Characterization and Molecular Docking Studies of Imidazolium Based Polyelectrolytes–DNA Complexes: Role of Hydrophobicity

Some selected aminophosphine oxides (AmPOs) and their corresponding La(iii) and Th(iv) complexes are synthesized and analyzed by FT-IR, 1H-NMR, 31P{1H}-NMR, elemental analysis and TGA data.

RSC Advances

Function of substituents in coordination behaviour, thermolysis and ligand crossover reactions of phosphine oxides

The extraction behavior of U(vi) &amp; Am(iii) with di-n-alkyl phosphine oxides (DAPOs) was investigated. DAPO behaves like an acidic extractant at low acidity and at higher acidity they extracted via cation exchange mechanism.

Experimental and theoretical studies on extraction behavior of di-n-alkyl phosphine oxides towards actinides

Some aminophosphine oxides (AmPOs), (R1)(R2)(R 3)P=O [R1=R2=R3= HNCH 2CH=CH2; R1= R2=Ph, R 3=HNCH2CH=CH2; R1=R 2=R3=HNNMe2; R1=R2=Ph, R3=HNNMe2; R1=R2=R3= NC4H8O; R1= R2=Ph, R3= NC4H8O], have been synthesized. The coordination chemistry of these AmPOs is studied with La(III), Th(IV), and U(VI) salts. The products are characterized by various analytical and spectroscopic techniques, and the thermal properties of the ligands and their complexes examined. The TGA data for these compounds show different decomposition temperatures, as well as thermal stability of the metal complexes. Comparisons are made among different ligands on their selective complexing ability towards some chosen metal salts. Mulliken population analysis shows that the basicity of P=O of ligand increases with an increase in the number of P-bonded amino groups. © 2013 Taylor &amp; Francis.

Journal	Data powered by TypesetInorganica Chimica Acta
Publisher	Data powered by TypesetElsevier BV
ISSN	0020-1693
Open Access	0