The influence of an antibiotic Co-Amoxiclavis studied for useas a low cost and ecofriendly corrosion inhibitor for mild steel in acidic environmentin particular to 1N hydrochloric acid medium. The corrosion inhibition effectand the performance of the inhibitorhasbeenextensively studied byweight loss studies, Tafelpolarization experiments, electrochemical impedance spectroscopy and hydrogen permeation measurements. The dosage of the antibiotic was varied from 5×10–4M to 15×10–4M. It has been established thatthe inhibitor performed well and showed 88% inhibition efficiency at 15×10–4Mconcentration of Co-Amoxiclavmolecules. The electrochemical studies such as Potentiodynamic polarization proposes thatthe antibiotic viz., Co-Amoxiclavacted as a mixed type of inhibitor. The increased charge transfer resistance and decreased double layer capacitance obtained from electrochemical impedance spectroscopyconfirmed that said antibiotic has performed as good inhibitor in 1N hydrochloric acid medium. Hydrogen permeation measurements showed that the compound acts as cathodic inhibitor, but predominantly under mixed control. It has been noticed that a definite correlation exists between chemical and electrochemical studiesfor the inhibition action ofCo-Amoxiclavmolecules on the corrosion of mild steel in 1N HCl medium. Diffused reflectance spectroscopy (DRS) studies established that only the mere adsorption of antibiotic on mild steel surface took place and not influence on the surface morphology. The adsorption of this compound on mild steel surface obeys Temkin’s adsorption isotherm.