Transition metal-free organic transformations using K2S2O8 is one of the most efficient methods for the formation of carbon-carbon/carbon-heteroatom bond in organic synthesis. K2S2O8-mediated transformations provide a cost-effective and green method for these type of transformations. In addition, these reaction methods are alternatives for many metal-mediated/catalyzed reactions. This article mainly describes the recent advances in K2S2O8-mediated cyclization/coupling reactions via oxidative transformation in organic synthesis in the last few years. This journal is © The Royal Society of Chemistry.