Punicalagin is an active compound found in the Pomegranate rind. The hallmark of the compound is its antioxidant properties which is more than most other sources such as Red wine. The poly-phenol donates hydrogen to free radicals like peroxynitrites and prevents it from oxidizing and destroying microglial cells in the brain. The compound has high bio-availability and is has reduced neuronal inflammation as well. The compound is useful for treating Alzheimer’s, Parkinson’s, Huntington’s and many other Dementia’s. Apart from its antioxidant properties, the compound is an antidermatophyte and antimicrobial. Punicalagin has also shown ability in down regulating virulent Quorum sensing genes in Salmonella.