A novel fluorescent receptor L was developed for the selective detection of important bioactive analytes.

Priyankar Paira

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Kumar R

Computer Science

School of Computer Science and Engineering

Chennai Campus

Upadhyay Y

Anand T

Babu L.T

Crisponi G

Sk A.K

Sahoo S.K.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Dalton Transactions

A new fluorescence receptor 2-(diethylamino)-N-(quinolin-8-yl) acetamide (L) was synthesized by simple reaction condition. The ligand HL is highly selective and sensitive towards Zn2+ ions over other tested metal ions. Upon interaction HL with Zn2+, the receptor HL showed a distinct fluorescence enhancement at 496 nm due to chelation enhanced fluorescence (CHEF) leading to visible fluorescence color change from blue to cyan. Subsequently, an in-situ generated L-Zn2+ when interacted with various anions, only with H2PO4− showed fluorescence quenching while other ions did not respond. Accordingly, the receptor HL was developed for the highly selective determination of Zn2+ and H2PO4− with the lowest detection limit (LOD) of 8 nM and 55 nM respectively. The binding mechanism of HL with Zn2+ and L-Zn2+ with H2PO4− were studied by both experimental and theoretical studies. The off-on-off sequential of HL with Zn2+ and H2PO4− were successfully employed for the INHIBIT logic gate response and cellulose assisted test strips proved, the practical application for qualitative analysis of Zn2+ and H2PO4− ions. Finally, the receptor HL was applied for the detection of Zn2+ in different water and pharmaceutical samples. © 2019 Elsevier B.V.

Inorganica Chimica Acta

An “Off-On-Off” type fluorescent chemosensor for the relay detection of Zn2+ and H2PO4− in aqueous environment

This manuscript introduced a new optically active chemosensor L containing rhodamine 6G as the fluorogenic unit and the vitamin B6 cofactor pyridoxal 5′-phosphate (PLP) as the metal ions binding unit. Sensor L showed a significant turn-on fluorescence at 550 nm selectively in the presence of Al3+ and Cr3+ ions due to the complexation prompted opening of the spirocyclic ring. Using sensor L, the concentration of Al3+ and Cr3+ ions can be detected down to 0.41 µM and 2.33 µM, respectively. Sensor L formed a metal complex in 1:1 binding stoichiometry in solution with the estimated binding constant of 11,310 M−1 and 8373 M−1 with Al3+ and Cr3+, respectively. The probable 3D structure and the electronic properties of L and its complexes were proposed by semi-empirical PM6 method. Further, the bioimaging experiments were performed to examine the potential of L to detect the intracellular Al3+ and Cr3+ ions present in the live HeLa cells. © 2019 Elsevier B.V.

Vitamin B6 cofactor conjugated rhodamine 6G derivative: Fluorescent turn-on sensing of Al(III) and Cr(III) with bioimaging application in live HeLa cells

Synthetically easy, a new chemodosimeter-type chromogenic and fluorogenic chemosensor L was developed by condensing 1-aminopyrene with the vitamin B6 cofactor pyridoxal for the selective detection of Fe3+. Receptor L exhibits a rapid colorimetric response from yellow to colourless and a distinct fluorescence enhancement at 441 nm with Fe3+ due to the cleavage of imine linkage. The optical responses from L in the presence of Fe3+ ions are highly specific, interference-free, can be monitored by smartphone and also observed within the live HeLa cells. © 2018 Elsevier B.V.

Journal of Photochemistry and Photobiology A: Chemistry

Combined use of spectrophotometer and smartphone for the optical detection of Fe 3+ using a vitamin B 6 cofactor conjugated pyrene derivative and its application in live cells imaging

European Journal of Inorganic Chemistry

A Highly Selective and Efficient Copper(II) - “Turn-On” Fluorescence Imaging Probe forl-Cysteine

N , N coordinating schiff base ligand acting as a fluorescence sensor for zinc(II) and colorimetric sensor for copper(II), and zinc(II) in mixed aqueous media

RSC Adv.

Cysteine-based fluorescence “turn-on” sensors for Cu2+ and Ag+

Journal of Materials Chemistry B

A mononuclear zinc complex for selective detection of diphosphate via ESIPT fluorescence turn-on

Chemical Communications

A fluorescent “2 in 1” proton sensor and polarity probe based on core substituted naphthalene diimide

Three-in-one type fluorescent sensor based on a pyrene pyridoxal cascade for the selective detection of Zn(ii), hydrogen phosphate and cysteine

Journal	Data powered by TypesetDalton Transactions
Publisher	Data powered by TypesetRoyal Society of Chemistry (RSC)
ISSN	1477-9226
Open Access	0