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To Screen Inactivation Mutation of Exon 1 of FSHR Gene in Polycystic Ovarian Syndrome: A South Indian Cohort Study
Sekar N, Yeole S, Pradeep R, Prabhu Y.D, Renu K, Ramgir S.S,
Published in IOP Publishing
Volume: 263
Issue: 2
Polycystic ovary syndrome is an endocrine disorder. Irregular menstrual cycle, acne, facial hair and elevated androgen levels are the most common signs for PCOS. PCOS has an estimated prevalence of 4-12% among reproductive age women, thus making it a forerunner in female infertility. FSHR plays an important role in FSH signaling pathway making it an important gene for PCOS. In this study, we aim to focus on any association between the FSHR gene and PCOS. Our study was to evaluate any polymorphism of exon 1 of FSHR gene associated with PCOS.PCR-RFLP technique was performed on the PCOS samples. Hormonal changes were found in the patients. Exon 1 inactivation mutation of FSHR gene was not observed in the patient sample. A study of this association needs to be done using large sample size. © Published under licence by IOP Publishing Ltd.
About the journal
JournalData powered by TypesetIOP Conference Series: Materials Science and Engineering
PublisherData powered by TypesetIOP Publishing
Open AccessNo