This book chapter scrutinizes the total synthesis of natural products extricate from fruits and vegetables and its biological activities allied to certain diseases. Generally, natural products are extricated from plants and their products. Which render nutrition, phytochemicals, vitamins, fibers, and minerals etc.., these are manifest numerous biological activities such as antioxidant, antibacterial, anti-inflammatory, and antifungal activity etc., hostile to chronic diseases like cancer, Alzheimer's, heart disease, arthritis, and asthma etc., at a certain level, and gift with good health. Natural products are present in the free form or associated with glycosides in little quantity, sometimes difficult to isolated in pure form. Therefore, total synthesis plays a major role in the current engrossment, synthesis and its study allied to biological activities. © Springer International Publishing AG, part of Springer Nature 2018.

Mohana Roopan S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Nasireddy Seshadri Reddy

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Total Synthesis of Natural Products Existence in Fruits and Vegetables

Bioorganic Phase in Natural Food: An Overview

Plants are the main source of medicine which is used in traditional as well as modern medicine in recent years for curing many diseases. Carissa edulis Vahl is one of the traditional plants which have healing property on diarrhea, toothache and chest pain. The present work aims on phytochemical, antioxidant and in vitro cytotoxicity test of C. edulis dried fruits. The different solvent extracts obtained from petroleum ether, ethyl acetate, chloroform, ethanol and water have been evaluated the presence of phytochemicals. Several assays were carried out like total antioxidant, DPPH, reducing power and thiobarbituric acid to investigate the free radical scavenging property. In addition, the cytotoxicity study also carried out on human lung cancer cells (A549). Among different solvent extract, ethanol exhibited strong antioxidant activity. Additionally, the in vitro cytotoxicity test of C. edulis on human lung cancer cell (A549) showed IC50 value 405.704 ± 2.42 $\mu$g/mL. Therefore, C. edulis could be useful as a potential preventive intervention for free radicals mediated diseases as well as an antioxidant drug in the pharmaceutical industry.

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IOP Conference Series: Materials Science and Engineering

Preliminary phytochemical analysis, Antioxidant and cytotoxicity test ofCarissa edulisVahl dried fruits

The present work describes the eco-friendly synthesis of silver nanoparticles using dried fruit extract of C. carandas. The synthesized AgNPs were characterized by UV-Vis analysis, FTIR, XRD, SEM and TEM with histogram. The TEM image of the precipitated solid phase of AgNPs showed in the range of 23 ± 2 nm in size. Further, the catalytic degradation on crystal violet dye in the presence of C. carandas dried fruit extract and AgNPs was also studied.

Inorganic and Nano-Metal Chemistry

Green synthesis and catalytic application of silver nanoparticles usingCarissa carandasfruits

The use of plant extract to synthesize nanoparticle has been considered as one of the eco-friendly method. Additionally, it is a strong alternate for conventional methods which includes chemical and physical approach. In this study, microwave assisted extraction of Carissa edulis (C. edulis) at 70 °C and 400 W was used to extract the secondary metabolites. Further, the metabolites were used as capping agent and Zn (NO3)2 as the metal precursor to synthesize ZnO nanoparticles (ZnO NPs). UV–Vis spectroscopy, FT-IR, XRD, SEM and HR-TEM were used for the characterization of nanoparticles. The Surface Plasmon Resonance around 358 nm from the UV–Vis spectroscopy result represents the ZnO NPs formation. The FT-IR confirms the presence of functional groups that acts as the capping agent for the synthesis of ZnO NPs. The crystalline structure of nanoparticles is revealed in the XRD result, morphology showed by SEM results and the size of the ZnO NPs were predicted by HR-TEM. We have carried out the photocatalytic degradation of Congo red at 365 nm in photo reactor using ZnO NPs. The result from the photocatalytic degradation Congo red showed rate constant is (− k) 0.4947 with 97{\%} of degradation. This is our first attempt on the C. edulis extract on ZnO NPs preparation and Congo red dye degradation revels that ZnO NPs exhibit good photocatalytic property.

Journal of Photochemistry and Photobiology B: Biology

Photocatalytic degradation of Congo red using Carissa edulis extract capped zinc oxide nanoparticles

Biosynthetic methods are alternative approaches which are much safer than the normal techniques (physical and chemical) used for the methods for synthesis of metal nanoparticles. The benefits are sample as it is economic and environment friendly. Herein present investigation, we have reported a microwave mediated eco-friendly synthetic approach for preparing cerium oxide (CeO2) nanoparticles. Here, we used Moringa oleifera peel as the stabilizing and reducing agent towards synthesize of Ce2O NPs via microwave irradiation. The NPs were further characterized using UV-Vis, FT-IR, XRD and HR-TEM techniques. The FTIR analysis confirmed the phytochemical involvement in NPs stabilization. The crystallinity of CeO2 nanoparticles are well demonstrated through X-ray Diffraction and HR-TEM. The TEM images reveal the spherical shape of the CeO2 NPs having an average size of 45nm. Additionally, these CeO2 NPs were used successfully as a catalyst in the degradation of the dye, crystal violet. Also the antibacterial activity of the synthesized CeO2 NPs was evaluated using Staphylococcus aureus (Gram positive bacteria) and Escherichia coli (Gram negative bacteria). CeO2 NPs showed better activity on E. coli than S. aureus. We have demonstrated an eco-friendly preparation of CeO2 nanoparticles, a good photocatalyst and having better antibacterial properties.

Photocatalytic and antibacterial properties of phytosynthesized CeO2 NPs using Moringa oleifera peel extract

The photochemical synthesis of a series of 2,3-dihydroquinazolin-4(1H)-ones were evaluated under the irradiation of visible light ({\textgreater}390 nm). The effect of the visible light mediated synthesis was carried out in the presence/absence of solvent. The effect of solvent plays a key role in the synthesis was evidenced through the formation of product in short duration. The solvatochromic effects of the fluorescent compounds (3a-k) were studied with respect to the solvents of increasing polarity (DCM {\textless} methanol {\textless} DMF {\textless} DMSO). The determination of in vitro anti-inflammatory activity of the compounds (3a-k) by the inhibition of bovine serum albumin (BSA) denaturation and 2,2-di(4-t-octylphenyl)-1-picrylhydrazyl (DOPPH•) radical scavenging consequence of the compounds (3a-k) were determined by spectroscopic technique. The compound 3j in DMSO exhibited extreme high quantum yield. The compound 3i was found to be superior both in the efficiency of the anti-inflammatory activity and radical scavenging ability.

Journal	Data powered by TypesetBioorganic Phase in Natural Food: An Overview
Publisher	Data powered by TypesetSpringer International Publishing
Open Access	No