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Transition metal-catalyzed C H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides
Patil B.N, Lade J.J, Karpe A.S, Pownthurai B, Vadagaonkar K.S, , Chaskar A.C.
Published in Elsevier BV
Volume: 60
Issue: 13
Pages: 891 - 894
Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves C–H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields are notable features of this protocol. © 2019 Elsevier Ltd
About the journal
JournalData powered by TypesetTetrahedron Letters
PublisherData powered by TypesetElsevier BV
Open AccessNo