Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves C–H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields are notable features of this protocol. © 2019 Elsevier Ltd

Mohanasrinivasan V

Department of Bio-Medical Sciences

School of Bio Sciences and Technology

Vellore Campus

Patil B.N

Lade J.J

Karpe A.S

Pownthurai B

Vadagaonkar K.S

Chaskar A.C.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

&nbsp;

&nbsp;

VIT University

Tetrahedron Letters

ChemistrySelect

Tandem Protocol for the Synthesis of 3-Acyl Benzothiadiazine 1,1-Dioxides

Advanced Synthesis & Catalysis

One-Pot Protocol for the Synthesis of Imidazoles and Quinoxalines using N-Bromosuccinimide

Asian Journal of Organic Chemistry

An Efficient Synthesis of Pyrrolo[1,2-a]quinoxalines by Copper-Catalyzed C−H Activation of Arylacetic Acids

Oxidative cyclization of amidoximes and thiohydroximic acids: A facile and efficient strategy for accessing 3,5-disubstituted 1,2,4-oxadiazoles and 1,4,2-oxathiazoles

ACS Chemical Neuroscience

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors

Transition metal-catalyzed C H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides

Journal	Data powered by TypesetTetrahedron Letters
Publisher	Data powered by TypesetElsevier BV
ISSN	0040-4039
Open Access	No