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Tumor Heterogeneity: An Important Determinant for Efficacy and Safety in Nanoparticle Anticancer Gene Therapy
Published in Elsevier BV
2018
PMID: 29477234
Volume: 36
   
Issue: 5
Pages: 476 - 477
Abstract
Models of tumor heterogeneity should mimic perfusion in the tumor mass and consider cancer stem cell hierarchy and convertibility. Other important factors include epigenomic alterations, enhanced permeation and retention effects, and the reticuloendothelial system. New stimuli-responsive delivery systems, active targeting-based methods, and corona characterization strategies can deliver genes more precisely. © 2018 Elsevier Ltd
About the journal
JournalData powered by TypesetTrends in Biotechnology
PublisherData powered by TypesetElsevier BV
ISSN0167-7799
Open AccessNo