Human body is a perfectly designed and the most effectively functioning biomachine. When there is no proper care microbes enter our body and lead to septicemia and makes us asthenic. Much of the pathogens gain entry into our body by contaminated food, water and physical contact with the affected person or material. Pathogens are biological fluids which disrupts homeostasis. The pathogens could be viral, bacterial, nematodal, prional or fungal. The impact of the infection depends on the pathogenicity of the infected pathogen. We are always concerned about the places that we see regularly and we hear frequently. We rarely thimk of certain sites that may cause us an infection. Not only drainages or an unclean surrounding is a place where pathogens grow; even nosocomial sites like catheters, ICU’s or operation theaters can be a site of infection. We never even think of these sites but we need to be cautious about such sites. Our own unclean habits lead us to various opportunistic infections from unnoticed sites like toothbrushes, currency notes etc. Our daily usage things like toiletries must be kept moisture free and clean. Moisture content in such things readily promote microbial growth. The reviewed article gives a brief outline of such unnoticed sites of infection. © 2020 All rights reserved.