The current research work is devoted to study the exploration of dissipation and chemical reaction on MHD radiative Casson nanoliquid thin film flow generated due to the sheet stretching. Brownian motion, viscous dissipation, radiation and chemical reactions are considered, respectively, in energy and concentration equations. The popularly used similarity variables are utilized to remodel the nonlinear partial differential equations to a system of ordinary differential equations. The computational results are obtained for this system by adopting shooting technique. The impressions of significant flow variables on liquid stream are obtained through diagrams and tables. The outcomes of current work conclude that the thickness of thin film decreases with the rise of unsteady, magnetic and Casson parameters. Also, for higher estimates of non-Newtonian parameter a reduction in the coefficient of wall friction is noticed. The outcomes are matched with the viscous fluid flow and the results are in better agreement as a limiting case. © 2021, The Author(s), under exclusive licence to EDP Sciences, Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature.