The aim of the study was to assess the comfort level and frequency in the use of information technology (IT) among nurses and analyze the relationship between various factors governing their use. A survey was conducted during 2013-14 at select Indian Hospitals of Tamil Nadu State. Correlation analysis and ANOVA test were used to analyze the data. The nurses working in the medium sized hospitals in the State are the study population. A random sample of 600 nurses was selected for the study. Gender, qualification and age level were analyzed to found the influence on use of computer hardware, communication and administrative related activities using computers. Effective and majority use of computers for information processing activities, communication, planning and policy development activities, finance, administration, education and research can lead healthcare organization to run their processes efficiently. Hospitals can provide appropriate computer training programs and computers access to nurses to realize the benefits from IT. Healthcare professionals may encourage nurses to use IT and computers at their work place by providing them attractive incentives. © 2015, Mediterranean Center of Social and Educational Research. All rights reserved.