In the title compound, C19H16ClNO2, the dihedral angle between the plane of the phenyl substituent and 3-acetyl-quinoline unit is 75.44 (5)°. The crystal structure is stabilized by inter-molecular C - H⋯O hydrogen bonds © 2009 Subashini et al.

Dr.Subashini Rajagopal

VIT Business School

Chennai Campus

Nawaz Khan F

Department of Chemistry

School of Advanced Sciences

Vellore Campus

R. Hathwar V

Maiyalagan T

Reddy G.G.K

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Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

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3-Acetyl-6-chloro-1-ethyl-4-phenyl-quinolin-2(1H)-one.

Acta Crystallographica Section E Structure Reports Online

Solvent-free, microwave-induced condensation of 2-aminoaryl alkyl ketones and ethyl 3-oxobutanoate in the presence of amberlite Na sr1L gave quinolinones in high yield when compared to other catalysts. Further, N-alkylation of the quinolinones was carried out effectively with various halides using amberlite Na sr1L. An N-alkylated quinolinone exhibited enhanced activities against B. subtilis, E. coli, and P. aeruginosa, similar to standard drug ampicillin. Two compounds showed effective activity against S. aureus, and one resulted in moderate activity against E. coli. © 2011 Springer-Verlag.

Monatshefte für Chemie - Chemical Monthly

Solvent-free synthesis and antibacterial studies of some quinolinones

The title compound, C18H16N2O, crystallizes in the triclinic space group P1, with four independent mol-ecules in the asymmetric unit wherein two mol-ecules have an irregular -ac, -ac, +ap conformation (ap, antiperiplanar; ac, anticlinal), while the other mol-ecules exhibit a different, +ac, +ac, +ap conformation. The planar (r.m.s. deviation = 0.006 Å in each of the four molecules) quinoline ring systems of the four mol-ecules are oriented at dihedral angles of 32.8 (2), 33.4 (2), 31.7 (2) and 32.3 (2)° with respect to the benzene rings. Intra-molecular N - H⋯N inter-actions occur in all four independent mol-ecules. The crystal packing is stabilized by inter-molecular N - H⋯O and C - H⋯O hydrogen bonds, and are further consolidated by C - H⋯π and π-π stacking inter-actions [centroid-centroid distances = 3.728 (3), 3.722 (3), 3.758 (3) and 3.705 (3) Å].

N-[2-(4-Methyl-2-quinolyl)phenyl]acetamide: aP1 structure withZ= 4

3-Acetyl-6-chloro-1-ethyl-4-phenylquinolin-2(1H)-one

Journal	Acta Crystallographica Section E Structure Reports Online
Publisher	International Union of Crystallography (IUCr)
ISSN	16005368
Open Access	0