Tuberculosis (TB) is one of the major health problems worldwide. Extensive efforts are in progress to eradicate TB using new drugs with new modes of action and with lesser side effects. The major challenge in this effort is the management of multi-drug resistant Mycobacterium tuberculosis strains. Nature has provided wider scope for the discovery of new lead molecules. Therefore, the purpose of this review is to underline the importance of plant derived drugs and to consolidate the literature pertaining to phytochemicals that have been proven to have antimycobacterial property. Owing to the vast literature, the inclusive criteria for selecting the phytochemicals for reviewing are the following: (a) the minimum inhibitory concentration (MIC) to be below 50 μg/ml and (b) capacity to manage the multi-drug resistant (MDR) and extensive drug resistant (XDR) strains. Though most of the phytochemicals discussed here have potential antimycobacterial property, the most promising candidates could be licarin A, dihydroguaiaretic acid, ursolic acid, oleanolic acid and plumbagin since these compounds were reported to inhibit wide variety of resistant strains as well as broad biological activity. We opine that these compounds or their respective analogs may eventually develop into effective drug candidate(s) against drug-resistant M. tuberculosis strains.