Traditional medicinal plants and herbs have been a pivotal part of treatment for many centuries. Acalypha indica (Euphorbiaceae) and Terminalia chebula possess high medicinal values and are used traditionally to cure various ailments for human beings. In this study, antioxidant activity, antibacterial activity, anti-inflammatory activity, cytotoxicity and apoptosis were evaluated. The methanolic extract of Acalypha indica showed 54 percent inhibition when compared to Terminalia chebula, which showed 43 percent of inhibition. Terminalia chebula has a zone of inhibition of 0.9 cm against Klebsiella pneumoniae, Proteus mirabilis, Lactobacillus acidophilus and Salmonella enterica and hence Terminalia chebula has more antibacterial activity than Acalypha indica. The MTT assay showed percentage inhibition in dose dependant manner. Also the percentage viability decreased as concentration increased when tested for the cyotoxicity of Acalypha indica when compared with doxorubicin. The DAPI staining showed that apoptosis is maximum at the 24th hour.