Marigold (Tagets erecta L.), being an ornamental plant, posses medicinal properties like antimicrobial, insecticidal, wound healing and blood coagulation properties. Our recent works mainly focus on blood clotting activity of marigold leaf extracts. Blood clotting activity of leaf extract was examined using prothrombin time (PT) test by Owren method. The optimization of marigold leaf coagulating activity at different concentration of leaf extract and blood was done with Response surface method (RSM). Experiments showed that there was decrease in coagulation time with increase in extract concentration. Marigold leaves extract has shown very good blood coagulation property in lesser quantity i.e., in the range of μl. Also, phenolic compounds (like gallic acid, scopoletin, ferulic acid, quercecetin) were identified and quantified, which shows that because of presence of them, marigold leaf extract shows coagulation property. Antifungal, antibacterial and antioxidant activity are also analyzed. From the above findings, it can be concluded that along with antibacterial, antifungal and antioxidant properties, marigold leave extracts are also having very good coagulation property; so, in further research it can be developed as an antiseptic with coagulation property and can be developed as a potent product in the field of medicine and ointment.