Buoyancy-driven mixed convection flow of a Nanofluid from a non-isothermal wedge has been investigated numerically using an implicit finite difference scheme. The model used for Nanofluid includes the effects of Brownian motion, buoyancy ratio and thermophoresis. A non-similarity solution is developed which depends on the Prandtl number (Pr), Schmidt number (Sc), Brownian motion number (Nb), buoyancy ratio parameter (Nr), thermophoresis number (Nt), mixed convection parameter (λ) and pressure gradient parameter (m). The variation of the skin friction, the reduced heat transfer rate and reduced mass transfer rate with Nb, Nr and Nt for various values of Pr, m and Sc are also tabulated. © 2018 by American Scientific Publishers All rights reserved.