In Multicarrier Code Division Multiple Access (MC-CDMA) system, the performance can get degraded due to a high Peak to Average Power Ratio (PAPR) which is equivalent to Peak to Mean Envelope Power Ratio (PMEPR) and Multi Access Interference (MAI). There are several methods to reduce the PAPR and MAI. Out of these, one of the methods is to use an efficient spreading code technique to reduce the PAPR and MAI. Here, the PAPR and MAI have been analysed using Walsh Hadamard sequence, Gold sequence, Gordon, Mills and Welch (GMW) sequence and de Bruijn sequence as the spreading code. Simulation results show that the de Bruijn sequence can provide lower PMEPR than that provided by the other spreading sequences. It is also found that the same de Bruijn sequence provides better MAI performance than the other sequences. So, in this paper it is proposed that the de Bruijn sequence can be used as a spreading sequence for MC-CDMA to reduce the PMEPR along with MAI in a MC-CDMA system. © School of Engineering, Taylor’s University.