We propose a sixfold photonic quasi-crystal fiber with a trapezoidal analyte channel based on surface plasmon resonance for the detection of high-refractive-index (RI) liquid analytes and numerically analyze its sensing performance for different liquid analyte refractive indices and heights using the finite-element method. In contrast to the common D-shaped structure photonic crystal fiber, we design a trapezoidal analyte channel to investigate the role of the sample liquid height within the channel and discussed the feasibility of the fabrication process. We find that with various liquid analyte heights ratios of 20%, 25%, 30%, and 50% of the maximum channel height, the proposed biosensor exhibits linear sensing performance with a maximum RI sensitivity of 4400, 6100, 8000, and 17000 nm/RIU, respectively, for analytes RI range of 1.44-1.57, 1.41-1.51, 1.40-1.49, and 1.40-1.44. This sensor is suitable to detect various high RI chemicals, biochemicals, and organic chemical samples. Owing to its simple structure of the proposed biosensor with promising linear sensing performance, we envisage that this biosensor could turn out to be a versatile and competitive instrument for the detection of high-RI liquid analytes. © 1995-2012 IEEE.