The main intention of the organization is to focused on enhancing its efficiency, life cycle, and productivity by maintaining better delivery time so that customer satisfying can be guaranteed. One way to achieve this intention is by implementing the concept of Total Productive Maintenance (TPM). In this study, barriers faced by Indian manufacturing organizations in the new emerging market had been determined through the questionnaire survey with the help of renowned academician and industrial experts. These barriers had been divided into key areas namely behavioral, organizational, cultural, technological, departmental, operational, and financial barriers. The barriers had positive as well as negative effects on the actual implementation of TPM aligned with life cycle engineering of productive equipment. The study identifies the crucial barriers to TPM employment in Indian manufacturing industries from the literature review and industrial experience. Hence, a unique model was developed for the determination of the driving and dependence power of the barriers to TPM execution to enhance the life cycle of productive equipment using Interpretive Structure Modelling (ISM). © 2021 Elsevier B.V.. All rights reserved.