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Dual Stage Normalization Approach Towards Classification of Breast Cancer
M.A. Aswathy,
Published in Taylor and Francis Ltd
Breast cancer is a major concern among women that causes high risk of death. Early diagnosis of such cancer becomes challenging due to alterations in the color of the histopathological breast images. This study uses a publicly available dataset of breast cancer histopathology images. This paper introduces a dual stage normalization approach, to address the color variation problem of biopsy specimen collectively caused by incompatible staining in biopsy process and bizarre imaging quality. The dual stage normalization proposed here consists of a stain normalization unit and a light normalization unit. This system addresses the variations of both imaging and staining of specimen that are caused by a microscopic imaging setup. Later on, eight features have been extracted from the normalized images and used for the classification of breast cancer (benign and malignant). The overall accuracy of the back propagation algorithm (BPA) classifier is obtained as 81.8%. After comparison with other classifier accuracies, BPA classifier is found to be acceptable. Recall and precision values are approximately 89% and 90%, respectively, which is acceptable. The saturation-weighted hue statistics produces balanced and uniform color hues for stain normalization. This statistic is powerful against variations in model parameters and unsusceptible to image subjects and achromatic colors. This normalization technique retains all histological data with an enhanced performance. © 2020, © 2020 IETE.
About the journal
JournalData powered by TypesetIETE Journal of Research
PublisherData powered by TypesetTaylor and Francis Ltd