The analysis of entropy generation has received notable attention in the study of nanofluids because the prime objective of nanofluids is to admit high heat fluxes. The entropy production can be utilized to generate the entropy in any irreversible heat transfer process which is important in thermal machines. This work presents to explore the fluid transport characteristics and entropy generation of a tangent hyperbolic nanofluid over a horizontal circular cylinder with the influence of nonlinear Boussinesq approximation. The dimensionless nonlinear partial differential equations have been solved by using an implicit finite difference Keller box scheme. The impacts of active parameters on the flow field like Weissenberg number, power-law index, magnetic field, mixed convection, Brownian motion, thermal convention, thermophoresis and radiation are illustrated with graphs and tables. The current results exposed that the nanofluid velocity enhances for enhancing the mixed convection parameter. Isotherms thickness is escalated with increasing values of radiation parameter. Total entropy generation rises for higher values of dimensionless temperature ratio parameter. © 2020, Akadémiai Kiadó, Budapest, Hungary.