Air pollution due to fine particulate matter (PM2.5) concentration in Indian cities is becoming a major threat to human health. The most common short-term effects of PM2.5 are chronic obstructive pulmonary diseases (COPD). This COPD health effect is associated with high monetary burden on people residing in urban population. Thus, it is crucial to evaluate short-term COPD hospital admissions and monetary burden caused by PM2.5. In the present study, the Hyderabad city in India is chosen as a model city for evaluation. The AirQ+ software developed by World Health Organization is utilized for quantifying COPD hospital admission. Using AirQ+ software, the estimated attributable proportion (EAP), excess number of attributable cases (EAC), and estimated number of attributable cases per 1 lakh people (EACP) related to COPD hospital admissions are quantified. Further, the cost of illness (COI) method and value of statistical life (VSL) methods are adopted for estimating the monetary burden. The required annual mean PM2.5 data is downloaded from Central Pollution Control Board website. Results showed that Hyderabad has an EAP of 7.12% in 2016 and 7.88% in 2017. Total EAC in our study period is found to be 2,97,848 cases, and the monetary burden in 2016 and 2017 are estimated to be 4998 and 5522 million INR, respectively. Also, the VSLHyderabad is estimated to be 34,17,224 INR. © 2020, Springer Nature Singapore Pte Ltd.