Ethanolic extracts of Emblica officinalis, Eculaptus globules and Cymbopogon citratus were taken for this research work to elucidate their anti-oxidant, anti inflammatory and anti bacterial activity against skin diseases and to formulate an emulsion based cream. 2, 2-diphenyl-1-picrylhydrazyl test and DNA protection test was carried out to evaluate anti oxidant activity. Four different anti inflammatory assays, namely albumin denaturation, HRBC membrane stabilization, anti-proteinase and heat induced hemolysis were performed. The anti bacterial activity was evaluated using microtitre well dilution method against S.aureus and S.pyogenes. Maximum anti oxidant activity was found in the case of E.officinalis (84.37 %) whereas C.citratus was good DNA protecting agent (16.98%). Anti inflammatory tests yielded maximum inhibition for E.globulus (91.32%). E.officinalis showed a promising result for anti-bacterial (MIC90 of S.aureus= 0.251mg/ml and of S.pyogenes=0.325mg/ml). The cream retained its original property only at the RT (pH=6.55, viscosity=12.2cps, Spreadability=14.88 g.cm/s). © 2016, Global Research Online. All rights reserved.