The reflection of green chemistry for the synthesis of a wide range of compounds via multi-component reaction systems is discussed in this paper. It also describes the most interesting, atom-economic Mannich and Mannich type reactions, their processes via green methods, solvents, green solvents, solvent effects, catalysts, catalyst effects, selectivity, kinetics, etc. They are indeed environmentally and ecologically benign. © 2014 Bentham Science Publishers.

Madhuri W

Department of Physics

School of Advanced Sciences

Vellore Campus

Sathiyanarayanan K

Department of Chemistry

Sreevalli W

Ramachandran G

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Green Trends in Mannich Reaction

Mini-Reviews in Organic Chemistry

Selective synthesis of 2,4-diaryl-2,3-dihydro-3H-naphtho[1,2-e]-1,3-oxazines and Schiff bases ((E)-[1-arylmethyl(benzylideneamino)]naphth-2-ols) that contain two identical or two different aryl substituents was achieved through one-pot synthesis with ammonium acetate. From the proposed mechanism the dual role of ammonium acetate was identified. The synthesized products were characterized by 1H and 13CNMR spectroscopy, as well as FTIR and mass spectrometry. Crystal structures of the 1,3-oxazines and Schiff base derivatives were examined. A notable feature is the conspicuous absence of strong donors (NH/OH) in any intermolecular hydrogen-bonding scheme. Instead, packing is characterized by weak intermolecular C-H{dot operator}{dot operator}{dot operator}O, H{dot operator}{dot operator}{dot operator}π and C-Cl{dot operator}{dot operator}{dot operator}π interactions, which lead to dimeric and zig-zag one-dimensional molecular patterns. The oxazine moiety of the tricyclic ring system predominantly adopts a half-chair conformation. The present Mannich procedure is an environmentally benign and cost-effective method for the preparation of industrially and pharmaceutically useful heterocyclic scaffolds. One way or the other: Selective synthesis of 1,3-oxazines 4a-d and 4k-m and Schiff bases 4e-j that contain two identical or two different aryl substituents was achieved through a one-pot synthesis by using ammonium acetate as a dual-purpose reaction component. The Mannich procedure with electron-poor aldehydes gives the oxazine products, whereas electron-rich aldehydes give the Schiff base products. © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.

Asian Journal of Organic Chemistry

Selective Synthesis and Structural Confirmation of 1,3-Oxazines and Schiff Bases with Controllable Substitution Patterns

The condensation of cyclic ketone with aromatic aldehydes in the presence of ammonium acetate under ethanol media affords the corresponding 5-aryl-7,8,13,14-tetrahydrodibenzo[a,i]phenanthridine with excellent yield. This mild and efficient procedure with high yield is also applied to the synthesis of 2,4-diaryl-6,7-benzo-3-azabicyclo-[3.3.1]nonan-9-ones and α,α'-bis(substituted benzylidene)cycloalkanones.

Bulletin of the Korean Chemical Society

Ammonium Acetate: An Efficient Reagent for the One-pot Synthesis of 5-Aryl-7,8,13,14-tetrahydrodibenzo[a,i] phenanthridines, 2,4-Diaryl-6,7-benzo-3-azabicyclo[3.3.1]nonan-9-ones and α,α'-Bis(substituted benzylidene)cycloalkanones

Chemical Papers

Ultrasound-assisted rapid synthesis of β-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature

Tetrahedron

One-pot synthesis of highly diversified tetrahydropyridines by tandem condensation of aldehydes, amines, and β-ketoesters

Journal of Sulfur Chemistry

Thioacetalization of aldehydes and ketones in SDS micelles

Journal	Mini-Reviews in Organic Chemistry
Publisher	Bentham Science Publishers Ltd.
ISSN	1570-193X
Open Access	0