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Longevity promoting efficacies of different plant extracts in lower model organisms
Chattopadhyay D,
Published in Elsevier BV
PMID: 29526449
Volume: 171
Pages: 47 - 57
Past investigations have shown that various plant extracts are capable of promoting longevity in lower model organisms like Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Bombyx mori etc. Longevity studies on such organisms provide a foundation to explore anti-aging efficacies of such plant extracts in higher organisms. Plant extracts of acai palm, apple, asparagus, blueberry, cinnamon, cocoa, Damnacanthus, maize, milk thistle, mistletoe, peach, pomegranate, Rhodiola, rose, Sasa, turmeric, and Withania have extended lifespan in lower model organisms via diverse mechanisms like insulin like growth factor (IGF) signaling pathway, and antioxidant defense mechanisms. Knowledge of pathways altered by the extracts can be investigated as potential drug-targets for natural anti-aging interventions. Thus, the aim of the review is to scrutinize longevity promoting efficacies of various plant extracts in lower model organisms. © 2018 Elsevier B.V.
About the journal
JournalData powered by TypesetMechanisms of Ageing and Development
PublisherData powered by TypesetElsevier BV
Open Access0