Diabetes mellitus is a metabolic disorder caused by oxidative strain or the loss of glucose homeostasis with the disorder of carbohydrate, fat and protein metabolism. It consequently affects insulin function and secretion. The growth and usage of synthetic drugs may cause side effects like mental illness or the other physiological imbalances. A new approach for treating diabetic complications is possible by using alternative medications from medicinal plants which possess many active bio-compounds. The plant sources consist of important phyto-constituents such as polyphenols, flavonoids, alkaloids and other components which acts against defective cellular metabolism and regulate its functional property. The variance in the cellular products helps to boost the body or cells against immune-complications caused by diabetes. The active compounds from the plants could be recorded and systematically validated to increase the plant-based medicines with fewer side effects or without side effects. The prolonged usage of synthetic drug can be replaced by natural form of supplements as it regulates mechanism against diabetes mellitus. © 2018 Research Journal of BioTechnology. All Rights Reserved.