One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different alcohols, afforded pyrano [3,2-c] chromene-3-carboxylates (5a-m) of the corresponding alcohols in good yield. The mechanism reveals that the alcohol (as solvent) plays a major role in the inter conversion of amide to the corresponding esters with Montmorillonite KSF (M-KSF) as a catalyst. Excellent yields, inexpensive and readily available substrates, environmentally benign reaction condition, shorter reaction time, and easy workup are the major advantageous features of this protocol. © 2018 Elsevier B.V.

Dr.Subashini Rajagopal

VIT Business School

Chennai Campus

Sumathi S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Subbareddy C.V

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Journal of Molecular Structure

Microwave-assisted montmorillonite K-10-catalyzed Friedlander synthesis of quinolinylquinolinones has been developed. The efficient and eco-friendly catalyst along with the convenience of the product isolation make this process an attractive alternative for the synthesis of target heterocycles. The synthesized products were confirmed by FTIR, 1H NMR, 13C NMR, and mass spectroscopic techniques. All the synthesized compounds showed good antibacterial property similar to standard Ampicillin and enhanced antioxidant activity. © 2014 Springer Science+Business Media Dordrecht.

Research on Chemical Intermediates

Microwave-assisted solid acid-catalyzed synthesis of quinolinyl quinolinones and evaluation of their antibacterial, antioxidant activities

An efficient strategy for the synthesis of 3-acetyl-2-methyl-1-phenylisochromeno [4,3-b] pyrrol-5(1H)-ones 4a–f have been developed using montmorillonite K10 as a catalyst. The synthesized compounds have prominent antioxidant activity and fluorescence properties.

RSC Adv.

Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues

A series of 2-(3,5-substituted-1H-pyrazol-1-yl)-3-substituted quinolines 5a–g, were obtained from 2-chloro-3-(1,3-dioxolan-2-yl) quinolines 2a–c and diketones 3a–c with great yields by utilizing Montmorillonite clay K-10 as a catalyst in an eco-friendly methodology. All the synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR and HRMS spectral techniques. Antibacterial screening of the compounds revealed that some of the compounds demonstrate moderate to good results. Amongst all, compound 2c displayed a good inhibitory profile against P. aeruginosa and B. subtilis, while compound 5c exhibited remarkable activity against S. aureus, B. subtilis and P. aeruginosa with an MIC value of 25 μg mL−1. Moreover, compound 5c presented a MIC value of 50 μg mL−1 against E. coli and K. pneumoniae, which was comparable to that of the standard. In addition, compound 5f was demonstrated good viability against S. aureus and P. aeruginosa with a MIC value of 25 μg mL−1. Compounds 2c and 5f, however, showed relatively moderate inhibition against S. aureus, while the latter had a moderate activity against B. subtilis. To further demonstrate the antibacterial efficacy of 2c, 5c and 5f, molecular docking studies were done, confirming that compound 5c possesses good binding interaction with the peptide deformylase protein, with a binding energy of −8.1 kcal mol−1—more prominent than that of standard ampicillin (−7.5 kcal mol−1)—while compounds 2c and 5f have moderate binding affinity.

Potential anti-bacterial agents: montmorillonite clay-catalyzed synthesis of novel 2-(3,5-substituted-1H-pyrazol-1-yl)-3-substituted quinolines and their in silico molecular docking studies

Solvent-free, microwave-induced condensation of 2-aminoaryl alkyl ketones and ethyl 3-oxobutanoate in the presence of amberlite Na sr1L gave quinolinones in high yield when compared to other catalysts. Further, N-alkylation of the quinolinones was carried out effectively with various halides using amberlite Na sr1L. An N-alkylated quinolinone exhibited enhanced activities against B. subtilis, E. coli, and P. aeruginosa, similar to standard drug ampicillin. Two compounds showed effective activity against S. aureus, and one resulted in moderate activity against E. coli. © 2011 Springer-Verlag.

Journal	Data powered by TypesetJournal of Molecular Structure
Publisher	Data powered by TypesetElsevier BV
ISSN	0022-2860
Open Access	0