This research paper tells about sustained delivery of small molecular drug ciprofloxacin using hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. Hydroxyapatite - poly (vinyl alcohol) nanocomposites are used as a vehicle to carry drug, protein, implantable materials etc. In situ synthesized hydroxyapatite hybrid poly (vinyl alcohol) matrix was characterized using different characterization techniques like XRD, SEM and FTIR. Small molecular drug ciprofloxacin was loaded into hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. The morphology of drug free and drug loaded hydroxyapatite concoction poly (vinyl alcohol) nanocomposites is observed using SEM. In-vitro drug release is quantified using UV/VIS spectrophotometer.