The new generation of systems are may using integration called cyber-physical system (CPS). It includes computational, control and communication capabilities. How humans are interconnected to the each other, CPS also interact physical objects as well. Currently, the study of CPS is still in its initial stages and there exist many research issues. The CPS integrating with medical devices is easy but handling their quires very quickly it is very difficult. In This paper proposed Real-Time big data computing for CPS enabled medical device association. It includes the many cyber physical enhanced secured Internet of things (IoT) integrated Big data steam computing platforms, and their architecture and its application to the Medical device monitoring and decision support systems is specified. Finally, a medical device associated with big data stream computing platforms. Produce high performance in overall medical device computing, communication, control, resource management and scheduling cores. © 2018 IEEE.