Heat and mass transfer effects on MHD three dimensional flow of Casson fluid over an exponentially stretching surface with slip conditions is examined. The similarity transformations are used to convert the governing equations into a set of nonlinear ordinary differential equations and are solved numerically using fourth order Runge-Kutta method along with shooting technique. The effects of Casson parameter, Hartmann number, heat source/sink,chemical reaction and slip factors on velocity, temperature and concentration are shown graphically. The skin friction coefficient and the Nusselt number are examined numerically. © Published under licence by IOP Publishing Ltd.