Aim: Peripheral vasculature of the human body includes the blood vessels that supply the extremities and the major vessels that supply the brain. Major peripheral vascular pathologies that affect the peripheral vasculature are arterial occlusive disease or stenosis (vessel narrowing), aneurysms (vessel enlargement) and various types of trauma. The aim of this study was to develop a peripheral vascular endovascular stent-graft for the treatment of various pathologies that affect peripheral vasculature, in particular, femeropopliteal arterial disease. The stent graft is composed of a nitinol framework covered by a polymeric tube. Methods: The present work explores an innovative device design which includes separate nitinol rings encased between layers of ePTFE. The vessel remodeling is studied by considering various vessel diameters and the efficacy of the device is studied by varying the nitinol wire diameter (0.1 to 0.25mm), the number of struts in the ring (6 to 10) and the height of the struts (1 and 2mm). Finite element studies were done to understand the best design for the changing vessel morphology by studying the crimping pattern and the radial stiffness of a single ring. A single ring is modeled as an axisymmetry FE-3Dmodel. An 8-node hexahedral element SOLID185 was used for this study. The nodes of the symmetric model were constrained and the radial displacement was given to the model. The boundary conditions were the same for crimping and deployment. Results: The results of the FEA analyses show 1 mm height ring with 0.15mm thickness and 8 struts combination provides the ideal crimped profile of 1.7mm and radial force of 0.996N/mm when deployed in a 6mm vessel diameter. Conclusion: The finite element analysis results show that the radial force and crimping analysis perform a vital role in determining the device design and geometry. © Springer International Publishing Switzerland 2014.