Servo pneumatic positioning system is a mechatronics approach that enables to use pneumatic cylinders as multi-position actuators. In the present study, an endeavor has been made to simulate the response of pneumatic cylinder parameters. Response surface methodology based analysis have been conducted to evaluate the influences of system parameters such as external load, supply pressure and cross sectional area of cylinder on the response characteristics such as settling time, maximum overshoot, integral time absolute error and maximum force generated using fuzzy rule base models. From the experimental results, it has been inferred that supply pressure has mostly influent nature on determining maximum overshoot and integral of time absolute error (ITAE). It has been observed that cross sectional area and external load has significantly affected the maximum generated force and settling time respectively. © 2014 Elsevier Ltd. All rights reserved.