In this study, Computational Fluid Dynamics (CFD) Analysis is used to investigate the flow in the centrifugal pump impeller using the ANSYS-CFX. Impeller is designed for head of 22 m, discharge of 52.239 m3/hr and for the operating speed of 2970 RPM. Impeller vane profile is generated by tangent arc method and CFD analysis is performed for 1st stage of vertical pump out of 15 stages. Velocity and pressure distribution are analysed for casing and impeller. Using ANSYS-CFX head developed by this impeller is calculated and compared with the required value. From results of CFD analysis, performance curves are plotted and compared with analytical performance curves. Results obtained from CFD nearly matches with analytical results.