New refrigerants are on the verge of hitting the automobile HVAC industry, on account of several threatening conditions. Zero ozone depletion potential (ODP) and low global warming potential are the major challenges looked at by many researchers. This paper, summarizes the challenges of experimenting R1234yf refrigerant for automobile HVAC system. Major factors considered are cost, efficiency, experiments, two-phase flow mechanisms, thermophysical properties, regulatory gauges, operation and maintenance. Survey results of the refrigerant reveal that, there is no evidence of breakdown. Apart from a significant reduction in global warming potential (GWP), R1234yf requires high work for the compressor with shorter cycle run-time of compressor. © TJPRC Pvt. Ltd.