This study investigates about machining practices used worldwide for machining of Inconel 718 super alloy. The effect of machining parameters like cutting speed, feed and depth of cut on machining responses like surface roughness and material removal rate when end milling Inconel 718 is studied using nine trials carried out based on L9 orthogonal array. A Taguchi based grey relational analysis was used for optimisation of machining parameters for high feed end milling operation on Inconel 718. An analysis of variance (ANOVA) was used to find the most significant factor. Validation of results through confirmation tests was performed and experimental results show that surface quality and productivity can be improved efficiently with this approach.