Since the invention of syringes 150 years ago not many design changes had been done on design. Syringe being one of the simple and effective drug delivery device used widely. In this paper an approach for redesign of the syringe is done considering the sustainability quotient of the design and material as well. By using the sustainable design principles, the aim is to reduce the material usage and optimize the design of the syringe. The sustainability study of the designed models were done using the solid works sustainability and the flow simulation. © 2015 Journal of Chemical and Pharmaceutical Sciences.