Combined cycle power plants, especially the combination of gas turbine and steam turbine power plants as the topping and bottoming cycles respectively, have been used for power generation for a long period of time. The resultant efficiency is greater than that of the individual cycles. This paper deals with the design and energy and exergy analysis of a 250 MWe combined cycle power plant. Exergy destruction was found to be maximum in the combustor, followed by gas turbine and steam turbine, and stack. Hence any effort to improve/optimize the combined cycle power plant must focus on the combustor and the turbines as they involve high irreversibilities. The energy and exergy efficiencies have been found to be 40.7% and 39.1% respectively. Also, part load performance at 200 MWe and 150 MWe has been conducted. © IAEME Publication.